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Mickey Goldberg's Lab
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We study the psychophysics and physiology of cognitive processes in the monkey, using single unit recording, iontophoresis, and careful behavioral measurements. Current projects include elucidation of the cortical representation of oculomotor proprioception, using saccadic adaptation to understand the coordinate system of neurons in the lateral intraparietal area (LIP), the role of prestriate cortex in visual search, and the role of inhibition in the response of parietal neurons. Recent discoveries in the laboratory include the demonstration of a predictive relationship of parietal activity to both saccadic reaction time and visual attention; the demonstration that the lateral parietal area acts as a linear summing junction for at least three independent signals: a saccadic signal, and undifferentiated visual signal, and a cognitive signal, and the proprioceptive representation of eye position in monkey area 3a of primary somatosensory cortex.
Mickey is now the President-Elect of the Society for Neuroscience --
If you thought it was hard to find him before, now it's impossible!
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People
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Michael E. Goldberg
• David Mahoney Professor of Brain & Behavior,
Neuroscience, Neurology, Psychiatry, Ophthalmology;
• Director, Mahoney Center;
• President-Elect, Society for Neuroscience
meg2008 [at] columbia [dot] edu
212.543.6931 x101
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mailing address:
Michael E. Goldberg, M.D.
Department of Neuroscience
Columbia University
1051 Riverside Drive, Unit 87
Kolb Annex, Room 561
New York, NY 10032
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CURRENT SCIENTISTS
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STAFF
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Annegret Falkner
Graduate Student
alf2111 [at] columbia [dot] edu
212.543.6931 x109
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Anna Ipata
Postdoctoral Fellow
ai2019 [at] columbia [dot] edu
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Sara Steenrod
Graduate Student
scs2018 [at] columbia [dot] edu
212.543.6931 x107
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Xiaolan Wang
Postdoctoral Fellow
xw2135 [at] columbia [dot] edu
212.543.6931 x108
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Yixing Xu
M.D.-Ph.D. student
yx2109 [at] columbia [dot] edu
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Latoya Palmer
Lab Administrator;
Mahoney Center Administrator
lp2104 [at] columbia [dot] edu
212.543.6931 x100
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Yana Pavlova
Lab Technician
yana [at] mahoney [dot] cpmc [dot] columbia [dot] edu
212.543.6931 x154
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Glen Duncan
Technical Specialist III
gduncan [at] mahoney [dot] cpmc [dot] columbia [dot] edu
212.543.6931 x152
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John Caban
Machinist
jc3032 [at] columbia [dot] edu
212.305.6745
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SCIENTIFIC ALUMNI
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- Ari Blitz
Assistant Professor of Radiology (Neuroradiology), Johns Hopkins University
- Cathie Bushnell
Harold Griffith Professor of Anesthesia and Neurology, McGill University, Canada
- James Bisley
Assistant Professor of Neuroscience, UCLA
- Charlie Bruce
Associate Professor of Neuroscience, Yale University
- Carol Colby
Professor of Neuroscience, University of Pittsburgh
- Jean-Rene Duhamel
Director of Research, Institute of Cognitive Science at CNRS, Lyon, France
- Jay Edelman
Assistant Professor of Neuroscience, CUNY
- Ed FitzGibbon
Investigator, Laboratory of Sensorimotor Research, NEI, NIH
- Angela Gee
Science Teaching Fellow, Columbia University
- Jackie Gottlieb
Assistant Professor of Neuroscience, Columbia University
- Ryohei P. Hasegawa
Investigator, Electro-technical Institute, Tsukuba, Japan
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- Morgan Jeffries
Resident in Neurology, Columbia University
- Suresh Krishna
Research Associate, Institute of Cognitive Science at CNRS, Lyon, France
- Makoto Kusunoki
Research Associate, Oxford University
- Carl Olson
Professor of Neuroscience, Carnegie Mellon University
- Keith Powell
Lily Pharmaceutical
- Mark Segraves
Associate Professor of Neuroscience, Northwestern University
- Marc Umeno
Microsoft
- Mark Walker
Associate Professor of Neurology, Case Western Reserve University
- Mingsha Zhang
Investigator, Institute of Neuroscience, Shanghai, China
- Ari Zivotovsky
Associate Professor of Neuroscience, Bar-Ilan University, Israel
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Publications
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RECENT PAPERS
Jeffries SM, Kusunoki M, Bisley JW, Cohen IS, Goldberg ME. (2007). Rhesus monkeys mislocalize saccade targets flashed for 100ms around the time of the saccade. Vision Res, 47, 1924-1934. [PDF]
Wang X, Zhang M, Cohen IS, Goldberg ME. (2007). The proprioceptive representation of eye position in monkey primary somatosensory cortex. Nat Neurosci, 10, 640-646. [PDF]
Ipata AE, Gee AL, Gottlieb J, Bisley JW, Goldberg ME. (2006). LIP responses to popout stimulus are reduced if it is overtly ignored. Nat Neurosci, 9, 1071-1076. [PDF]
Ipata AE, Gee AL, Goldberg ME, Bisley JW. (2006). Activity in the lateral intraparietal area predicts the goal and latency of saccades in a free-viewing visual search task. J Neurosci, 26, 3656-3661. [PDF]
Krishna BS, Steenrod SC, Bisley JW, Sirotin YB, Goldberg ME. (2006). Reaction times of manual responses to a visual stimulus at the goal of a planned memory-guided saccade in the monkey. Exp Brain Res, 173, 102-114. [PDF]
Bisley JW, Goldberg ME. (2006). Neural correlates of attention and distractibility in the lateral intraparietal area. J Neurophysiol, 95, 1696-1717. [PDF]
Gottlieb J, Kusunoki M, Goldberg ME. (2005). Simultaneous representation of saccade targets and visual onsets in monkey lateral intraparietal area. Cereb Cortex, 15, 1198-1206. [PDF]
Awater H, Burr D, Lappe M, Morrone MC, Goldberg ME. (2005). Effect of saccadic adaptation on localization of visual targets. J Neurophysiol, 93, 3605-3614. [PDF]
Zivotofsky AZ, Goldberg ME, Powell KD. (2005). Rhesus monkeys behave as if they perceive the Duncker illusion. J Cogn Neurosci, 17, 1011-1017.
Hasegawa RP, Blitz AM, Goldberg ME. (2004). Neurons in monkey prefrontal cortex whose activity tracks the progress of a three-step self-ordered task. J Neurophysiol, 92, 1524-1535. [PDF]
Hasegawa RP, Peterson BW, Goldberg ME. (2004). Prefrontal neurons coding suppression of specific saccades. Neuron, 43, 415-425. [PDF]
Bisley JW, Krishna BS, Goldberg ME. (2004). A rapid and precise on-response in posterior parietal cortex. J Neurosci, 24, 1833-1838. [PDF]
Edelman JA, Goldberg ME. (2003). Saccade-related activity in the primate superior colliculus depends on the presence of local landmarks at the saccade endpoint. J Neurophysiol, 90, 1728-1736. [PDF]
Kusunoki M, Goldberg ME. (2003). The time course of perisaccadic receptive field shifts in the lateral intraparietal area of the monkey. J Neurophysiol, 89, 1519-1527. [PDF]
Bisley JW, Goldberg ME. (2003). Neuronal activity in the lateral intraparietal area and spatial attention. Science, 299, 81-86. [PDF]
Edelman JA, Goldberg ME. (2002). Effect of short-term saccadic adaptation on saccades evoked by electrical stimulation in the primate superior colliculus. J Neurophysiol, 87, 1915-1923. [PDF]
Umeno MM, Goldberg ME. (2001). Spatial processing in the monkey frontal eye field. II. Memory responses. J Neurophysiol, 86, 2344-2352. [PDF]
Edelman JA, Goldberg ME. (2001). Dependence of saccade-related activity in the primate superior colliculus on visual target presence. J Neurophysiol, 86, 676-691. [PDF]
Hasegawa RP, Blitz AM, Geller NL, Goldberg ME. (2000). Neurons in monkey prefrontal cortex that track past or predict future performance. Science, 290, 1786-1789. [PDF]
Powell KD, Goldberg ME. (2000). Response of neurons in the lateral intraparietal area to a distractor flashed during the delay period of a memory-guided saccade. J Neurophysiol, 84, 301-310. [PDF]
Kusunoki M, Gottlieb J, Goldberg ME. (2000). The lateral intraparietal area as a salience map: The representation of abrupt onset, stimulus motion, and task relevance. Vision Res, 40, 1459-1468. [PDF]
Gottlieb J, Goldberg ME. (1999). Activity of neurons in the lateral intraparietal area of the monkey during an antisaccade task. Nat Neurosci, 2, 906-912. [PDF]
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Cover of Nature Neuroscience, Vol 10 (5), associated with Wang et al 2007.
About the cover: An eye position signal is required by the cortex, but its source has long been unknown. In this issue, Wang and colleagues identify a proprioceptive eye position signal in primate primary somatosensory cortex. The cover is an abstract image inspired by these findings, courtesy of Ellen Levy.
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CLASSICS
Duhamel JR, Colby CL, Goldberg ME. (1998). Ventral intraparietal area of the macaque: Congruent visual and somatic response properties. J Neurophysiol, 79, 126-136. [PDF]
Gottlieb J, Kusunoki M, Goldberg ME. (1998). The representation of visual salience in monkey parietal cortex. Nature, 391, 481-484. [PDF]
Duhamel JR, Colby CL, Goldberg ME. (1992). The updating of the representation of visual space in parietal cortex by intended eye movements. Science, 255, 90-92. [PDF]
Duhamel JR, Goldberg ME, Fitzgibbon EJ, Sirigu A, Grafman J. (1992). Saccadic dysmetria in a patient with a right frontoparietal lesion: The importance of corollary discharge for accurate spatial behavior. Brain, 115, 1387-1402.
Goldberg ME, Bruce CJ. (1990). Primate frontal eye fields. III. Maintenance of a spatially accurate saccade signal. J Neurophysiol, 64, 489-508. [PDF]
Bruce CJ, Goldberg ME. (1985). Primate frontal eye fields: I. Single neurons discharging before saccades. J Neurophysiol, 53, 603-635. [PDF]
Bushnell MC, Goldberg ME, Robinson DL. (1981). Behavioral enhancement of visual responses in monkey cerebral cortex: I. Modulation in posterior parietal cortex related to selective attention. J Neurophysiol, 46, 755-772. [PDF]
Goldberg ME, Bushnell MC. (1981). Behavioral enhancement of visual responses in monkey cerebral cortex: II. Modulation in frontal eye fields specifically related to saccades. J Neurophysiol, 46, 773-787. [PDF]
Goldberg ME, Wurtz RH. (1972). Activity of superior colliculus in behaving monkeys. II. Effect of attention on neuronal responses. J Neurophysiol, 35, 560-574. [PDF]
Wurtz RH, Goldberg ME. (1971). Superior colliculus cell responses related to eye movement in awake monkeys. Science, 171, 82-84. [PDF]
REVIEWS
Goldberg ME. (2007). Studying the visual system in awake monkeys: Two classic papers by Robert H. Wurtz. J Neurophysiol, 98, 2495-2496. [PDF]
Goldberg ME, Bisley JW, Powell KD, Gottlieb J. (2006). Saccades, salience and attention: The role of the lateral intraparietal area in visual behavior. Prog Brain Res, 155, 157-175. [PDF]
Bisley JW, Goldberg ME. (2003). The role of the parietal cortex in the neural processing of saccadic eye movements. Adv Neurol, 93, 141-157.
Goldberg ME, Bisley J, Powell KD, Gottlieb J, Kusunoki M. (2002). The role of the lateral intraparietal area of the monkey in the generation of saccades and visuospatial attention. Ann N Y Acad Sci, 956, 205-215. [PDF]
Ross J, Morrone ME, Goldberg ME, Burr DC. (2001). Changes in visual perception at the time of saccades. Trends Neurosci, 24, 113-121. [PDF]
Colby CL, Goldberg ME. (1999). Space and attention in parietal cortex. Annu Rev Neurosci, 22, 319-349. [PDF]
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